CD8A and neoplasm: Furthermore, the density of CD8 T cells within the tumour nest tissue compartment was negatively correlated with the ɑSMA+ fibroblast barrier score indicating that the barrier score may reflect physical exclusion of CD8 T cells by ɑSMA+ fibroblasts (Spearman ρ = −0.42, p = 2e-06, Fig. 5i).