Furthermore, data from TCGA indicated that the expression of TRIM8 was negatively correlated with the levels of HNF1α target genes, including aldolase B (ALDOB), apolipoprotein C3 (APOC3) and transthyretin (TTR) in human HCC (Fig. 4F–H). This evidence concerns the gene APOC3 and hepatocellular carcinoma.