TRIM8 and liver cancer: Interestingly, clinicopathological analysis clarified that upregulation of TRIM8 in human HCC was significantly correlated with aggressive clinical and pathological characteristics including less tumor capsule (P = 0.0176), more portal vein tumor thrombus (PVTT) (P = 0.0156), more advanced Barcelona Clinic Liver Cancer (BCLC) stages (P = 0.0404) (Table 1).