Given the vast roles that EGFR and HGFR signaling plays in the physiology of epithelial cells (e.g., ranging from the regulation of proliferation and migration to controlling stem cell homeostasis) and the frequent aberrant regulation of these signaling pathways in human cancers, the discovery of a mechanism that links their signaling to mitochondrial energetics could provide insights into novel therapeutic approaches combining EGFR/HGFR- and mitochondria-targeted therapies. This evidence concerns the gene MET and cancer.