Similarly, in a mouse model of chronic myocarditis and dilated cardiomyopathy induced by coxsackievirus B3 (CVB3), the study found increased levels of Th22 and IL-22, along with upregulation of MMP-9 expression and downregulation of metalloproteinase inhibitor-1 (TIMP-1) expression [155]. The gene discussed is TIMP1; the disease is dilated cardiomyopathy.