In general, we found that TRIM8 and UHRF2 might affect the prognosis of osteosarcoma patients by influencing or cooperating with the p53 signaling pathway, TGF-beta signaling pathway, cell cycle, PI3K-Akt signaling pathway, IL-17 signaling pathway, necroptosis pathway, etc. The gene discussed is TP53; the disease is osteosarcoma.