While UHRF2 could not only interact with other Ub/UBL-related proteins that regulate Ub/UBL protein modification, it could also interact with PCNA, DNMT1, HDAC1, and TRDMT1, which participate in DNA replication, cell cycle progression, microRNAs in cancer, etc. (Fig. 5F). This evidence concerns the gene HDAC1 and cancer.