MMP2 and breast cancer: In addition, our studies showed that ISO specifically suppresses the invasion of UM-UC-3 and T24T cells in vitro by targeting the STAT1/FOXO1/MMP-2 axis [9] and the miR-137/GSK3β/HSP70/MMP-2 axis [12] and inhibits the development of invasive BC in mice following exposure to the bladder carcinogen N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in vivo [9].