While pooled odds ratio from a study comprising 1093 cases and 2637 controls found no association between XPD Lys751Gln polymorphism and oral cancer risk across all genetic models [21], another meta-analysis including 1202 cases and 1145 controls indicated no significant associations between XPD rs1799793 and rs13181 polymorphisms and overall oral cancer risk. This evidence concerns the gene ERCC2 and lip and oral cavity carcinoma.