CTSC and brain injury: Overexpression of cathepsin C aggravates neuroinflammation in a model of traumatic brain injury (TBI) via increased expression of macrophage chemoattractant chemokine, Ccl2, and neutrophil chemoattractant Cxcl2 [53], and genetic silencing of cystatin F resulted in increased demyelination, associated with increased Cxcl2 gene expression in the cuprizone model of demyelination [34].