LPL and coronary artery disorder: Consistent with these previous observations, a recent study in coronary artery disease patients reported a bell-shaped effect of apoCII concentrations on glycosylphosphatidylinositol high-density-lipoprotein binding protein-1 associated LPL activity, in which extremely high concentrations of apoCII were associated with reduced LPL activity levels comparable to that observed in the absence of apoCII (29).