Consistent with these previous observations, a recent study in coronary artery disease patients reported a bell-shaped effect of apoCII concentrations on glycosylphosphatidylinositol high-density-lipoprotein binding protein-1 associated LPL activity, in which extremely high concentrations of apoCII were associated with reduced LPL activity levels comparable to that observed in the absence of apoCII (29). This evidence concerns the gene APOC2 and coronary artery disorder.