Firstly, recently published work demonstrates that microglia depletion aggravates disease in GIFN mice19; secondly, transcriptomic and in vitro analyses suggest that IFN-α-stimulated microglia unlikely participate in effector pathways like phagocytosis20; and thirdly, our microglial-specific knockout experiment here showed no significant impact on neurological disease or survival in GIFN mice. This evidence concerns the gene IFNA1 and nervous system disorder.