Recently, advances in Simoa technology, using super-affinity pan-IFN-α antibodies derived from individuals with AIRE-deficiency, have facilitated ultrasensitive quantification of IFN-α concentrations,4 allowing for the accurate comparison of IFN-α concentrations in different human fluid compartments such as blood and CSF. Here, IFNA17 is linked to hyperinsulinemic hypoglycemia, familial, 4.