IFNA1 and Aicardi-Goutieres syndrome: Using this approach, we demonstrated that elevated systemic IFN-α is not associated with the development of cerebral microangiopathy, and those individuals with very high concentrations of serum IFN-α (i.e., blood concentrations typically observed in individuals with AGS, >10 fg/mL) did not have more SVD in the CNS than those with lower concentrations.