MSMB and Familial prostate cancer: The most statistically significant associations per standard deviation increase in protein level, with evidence of colocalisation were seen for MSMB (a protein that is specifically expressed in the prostate) with a lower risk of all prostate cancer endpoints [OROverall = 0.81, 95% CI: 0.79–0.82, PP4: 100%; ORAggressive = 0.84, 95% CI: 0.82–0.86, PP4: 0.99; OREarly Onset = 0.71, 95% CI: 0.68–0.74, PP4: 1.0, Table 1, Fig. 2].