RAB8A and prostate cancer: The protein was also found to be expressed in prostate tumour tissue and may have a role in determining the invasiveness of PTEN-positive prostate cancer cells, according to GWAS and expression data from The Cancer Genome Atlas, and in a cellular study.54, 55, 56 While mechanisms that may link EHBP1 to prostate cancer risk are not yet fully described, it has a role as an effector molecule for Rab8 family members that modulate polarised membrane transport via actin reorganisation and may have a role in the mechanism of action for atorvastatin.55