Pharmacological conditioning: Notably, drugs such as angiotensin-converting enzyme (ACE) inhibitors, statins, and angiotensin-receptor blockers, which boost NO levels, show benefits in mouse models of myocardial infarction (MI), supporting the potential importance of NO in conditioning cardioprotection [46, 100, 149, 150, 179]. The gene discussed is ACE; the disease is myocardial infarction.