Nevertheless, the pro-inflammatory microenvironment with high levels of IFN-γ and GM-CSF could drive the polarization of neutrophil towards an APC-like phenotype with enhanced anti-tumor activities, characterized by the expression of co-stimulatory molecules OX40L, CD86 and 4-1BBL, which also possesses antigen presenting capability to stimulate T cell-mediated immune responses in the early stage of lung carcinoma [47]. This evidence concerns the gene TNFSF4 and neoplasm.