SD formation in mammals might require activities similar to those fulfilled by Scramb1 in Drosophila. Although till date no known functions have been ascribed to PLSCR proteins during SD formation in mammals, it is worth mentioning that transcriptomic data indicate that PLSCR2, a mostly uncharacterized protein, is enriched in podocytes in mice [64], and that PLSCR1 is one of the genes with most decreased expression in glomerular samples from patients with diabetic nephropathy [65], making these genes good candidates for further exploration. The gene discussed is PLSCR1; the disease is diabetic kidney disease.