MAPT and hyperhomocysteinemia: The findings regarding hyperhomocysteinemia and abnormal perception might be explained by (1) an indirect mechanism through tau phosphorylation because hyperhomocysteinemia, when caused by low vitamin B12 levels, promotes tau phosphorylation through the regulation of GSK3beta and PP2A45 and (2) genotype‐derived enzymatic deficiency given by the A1298C genetic variant of the methylenetetrahydrofolate (MTHFR) reductase.46, 47