In addition, findings from both in vitro and in vivo models indicate that deficiency in cysteine sulfase (NFS1) synergistically induces PANoptosis by elevating intracellular ROS levels and activating caspase-8 and caspase-9, respectively, suggesting that inhibition of NFS1 could be used as a promising strategy to improve prognosis of platinum-based treatment in colorectal cancer (Fig. 4B) [108]. This evidence concerns the gene NFS1 and colorectal cancer.