RT-qPCR analysis revealed that the expressions of ALKBH5, Runx2, MMP1, MMP2, MMP3, MMP9, MMP10, MMP12, MMP15, ADAMTS9, ADAMTS10, ADAMTS13, ADAMTS14, and ADAMTS20 were significantly higher in IDD patients than in the control group, while YTHDF1 expression was lower (Fig. 10D and R). This evidence concerns the gene MMP15 and intervertebral disk degenerative disorder.