METTL3 and colorectal carcinoma: We used three lentiviral shRNA vectors to knock down METTL3 in CRC cells, among which sh-METTL3 1# was the most effective (Fig. 6C), and RT-qPCR assay also revealed a significant decrease in circ_0008345 expression after knockdown of METTL3 (Fig. 6D).