Further studies showed that miR-17-5p could directly bind to mRNA 3 '-UTR to inhibit the expression of MPM, and the up-regulation of miR-17-5p was significantly correlated with the down-regulation of MPM in HCC tissues [178].CircSEMA4B and peptide SEMA4B-211aa were expressed at low levels in breast cancer(BC) and exerted as tumor suppressors in vivo and in vitro. This evidence concerns the gene MTLN and hepatocellular carcinoma.