DIDO1-529aa could interacted with both 1–372 aa and 525–1014 aa domains of PARP1 protein, which not only inhibits the binding of PARP1 to damaged DNA and the enzymatic activity of PARP1, but also increased levels of cleaved caspase 3 and cleaved PARP1 in GC cells, and finally inhibits the apoptosis and transfer of GC cells [166]. The gene discussed is CASP3; the disease is gastric cancer.