Importantly, IHC staining for cleaved caspase-3, β-catenin, and collagen II showed that in IDD and IDD + LV-NC groups, cleaved caspase-3 and β-catenin expression levels were increased, while the expression level of collagen II decreased significantly, indicating that NPC apoptosis and ECM catabolism increased in the process of IDD. This evidence concerns the gene CASP3 and nasopharyngeal carcinoma.