Moreover, S100A6 is also involved in non-neoplastic diseases, such as Alzheimer’s disease (Boom et al. 2004), amyotrophic lateral sclerosis (Hoyaux et al. 2000), epilepsy (Jurewicz et al. 2013), acute lymphoblastic leukemia (Pui et al. 2002), osteoarthritis (Lourido et al. 2021), and endometriosis (Gomes et al. 2018). This evidence concerns the gene S100A6 and osteoarthritis.