In the process of IDD, many inflammatory factors such as IL-1β, IL-6, IL-7, tumor necrosis factor-α accumulation in the IVD, causing the imbalance of catabolism and anabolism, leading to the structural changes of the IVD and promoting the progress of IDD (Risbud and Shapiro 2014). Here, IL1B is linked to intervertebral disk degenerative disorder.