Alterations of CDKN2B, KMT5B, and PIK3CA were significantly different between the two groups, with higher alteration rates in the hemorrhage group (CDKN2B, 84.4% vs. 62.2%, p = 0.029; KMT5B, 25.0% vs. 8.9%, p = 0.029; and PIK3CA, 81.3% vs. 58.5%, p = 0.029), indicating that these molecular alterations may relate to the occurrence and potential mechanism of intratumoral hemorrhage. This evidence concerns the gene CDKN2B and hemorrhage.