IDH1 and astrocytoma (excluding glioblastoma): In the subgroup analysis of astrocytoma (IDH mutant, WHO grade 2 and 3), oligodendroglioma (IDH mutant and 1p/19q co-deleted, WHO grade 2 and 3) and astrocytoma (IDH mutant, WHO grade 4), the cox regression result showed no significant impact of hemorrhage on prognosis (Figure S2, Figure A-C).