As HLA-G and VEGF were secreted in the CM collected from MM cells cultured under hypoxia (Fig. 2A), HLA-G and VEGF were individually depleted in the CM using neutralized antibodies, and HLA-G-depleted and/or VEGF-depleted CM were used to culture HUVEC for in-vitro angiogenesis studies. Here, HLA-G is linked to Miyoshi myopathy.