Specifically, CD86 + myeloid DC AC (OR = 1.03, 95% confidence interval (CI) 1.021–1.039, P = 2.04e − 09) and CD20- CD38- AC (OR = 1.072, 95% CI 1.036–1.109, P = 2.28e − 03) demonstrated a significant positive causal effect on AAA risk. This evidence concerns the gene CD38 and triple-A syndrome.