CD24 on sw mem (OR = 0.922, 95% CI 0.914–0.929, P = 2.62e − 79) and CCR2 on monocyte (OR = 0.978, 95% CI 0.971–0.986, P = 1.99e − 06) demonstrated a significant negative causal effect on AAA risk. This evidence concerns the gene CD24 and triple-A syndrome.