Mice deficient in Abin1 and mice expressing a severely compromised variant of Abin1 develop TNF-triggered embryonal lethality (Oshima et al, 2009; Li et al, 2022) or a severe autoimmune disorder (Nanda et al, 2011), depending on the character of the Abin1 modification and/or the genetic background of the mice. This evidence concerns the gene TNIP1 and Autoimmunity.