One potential direction for future research is the role of ABIN1 in adoptive cancer therapies using T cells with chimeric antigen receptors consisting of a canonical TCR signaling unit (ZETA chain) and TNFR superfamily signaling domain (CD137) (Singh and Maus, 2023), both potentially regulated by ABIN1. The gene discussed is TNFRSF1A; the disease is cancer.