TNIP1 and diabetes mellitus: Accordingly, the ABIN1-deficient OT-I T cells were more potent in inducing experimental diabetes than their WT counterparts measured as glucose in the blood and urine, insulitis, and immune cell infiltration in pancreatic islets, and OT-I expansion in the spleen (Figs. 6F–I and EV6G,H), suggesting that Abin1GTKO/GTKO T cells have a supraphysiological ability to undergo antigen-induced expansion, effector cell formation, tissue infiltration, and target cell killing, which enables them to escape the peripheral tolerance largely established by Tregs in this model (Tsyklauri et al, 2023).