We conclude that in mice M28 and M29, CLL clone growth was supported by autologous T-cells, but notably, it led to the clonally related engraftment in mice with HS5-CD40L-IL4 co-transplantation (M29) and clonally unrelated engraftment in control mice (M28, Supplementary Table 16). The gene discussed is CD40LG; the disease is B-cell chronic lymphocytic leukemia.