Analysis of BCL2 family members revealed complex changes in their expression, including induction of anti-apoptotic BCL-XL, BCL2 and MCL1 in CLL cells co-cultured with HS5-CD40L-IL4 and their relative repression in HS5-CD40L-IL4-IL21 co-cultures (Supplementary Fig. 2Ei). Here, CD40LG is linked to B-cell chronic lymphocytic leukemia.