CNTNAP2 is located on chromosome 7q35 and encodes a presynaptic type I transmembrane protein CASPR2, which is involved in cell–cell adhesion and synaptic interactions in the nervous system16.CNTNAP2 is associated with various neurodevelopmental disorders such as tic-toilet syndrome, intellectual disability, autism spectrum disorder (ASD), and schizophrenia17. This evidence concerns the gene CNTNAP2 and neurodevelopmental disorder.