CXCL12, CK7, CDH1, CTNNB1, TGFBR2 and CD44v6 were upregulated in CTC as well as cfRNA (Fig. 2A and C) whereas all these genes were downregulated in exosomes of primary lung cancer with and without metastasis (Fig. 2B). This evidence concerns the gene TGFBR2 and lung cancer.