[3H]OXD-2314 was also found to bind non-selectively to 3 R/4R-tau aggregates in AD tissues with a Kd of 3.6 ± 0.7 nM and to 3R-tau aggregates in PiD tissues with a Kd of 1.1 ± 0.2 nM. This evidence concerns the gene MAPT and Alzheimer disease.