Thus, in solid tumors recurrent translocations might be selected by different mechanisms than in hematologic malignancies, such as B-cell lymphoma, in which recurrent translocation are largely dictated by the off-target activity of the activation-induced cytidine deaminase (AID) and the recombination activating gene (RAG)1/2 enzymes55,61,62. Here, RAG1 is linked to hematologic disorder.