DSCC1 and cancer: These efforts are supported by a recent study on the proteomic landscape of MN following genotoxic stress.5 It would be very exciting to transfer this methodology to MN formed spontaneously in cells or mice defective for the genes identified in the landmark study by Adams and colleagues, such as DSCC1. Altogether, this expanding knowledge on MN should pave the way to develop new strategies for the treatment of human cohesinopathies and cancers with chromosomal instability.