DSCC1 and cancer: A recent study by Adams and colleagues published in Nature unveiled more than one hundred genes that are involved in micronucleus formation,1 which is a biomarker for genomic instability and associated with aging, cancer, and other disorders.2 As an outstanding achievement, the authors identified DSCC1 (DNA Replication And Sister Chromatid Cohesion 1) as a critical gene protecting against early developmental defects, genomic instability, reduced proliferative capacity, cohesinopathy-related phenotypes, and tumor development in vivo.1