Significantly, DUSP22 failed to inhibit colony formation in EGFRlow H520 and TC-1 cells (Fig. S2D), suggesting that DUSP22 predominantly acts on EGFR and hinders EGFR signaling to impede lung cancer cell proliferation via dephosphorylation, regardless of their EGFR mutation status. The gene discussed is DUSP22; the disease is lung cancer.