CASP3 and amyotrophic lateral sclerosis: On the other hand, the malfunctioning of ATXN2 has been associated with many diseases, especially spinocerebellar ataxia type 2 (SCA2) [8–10] and amyotrophic lateral sclerosis (ALS), but also parkinsonism, SCA1, SCA3, obesity, and diabetes [3, 11–19].