Among the six detected motifs, four were highly similar to the known consensus motifs HNF1B (P = 10−38), NEUROG2 (P = 10−32), FOXA1 (P = 10−23), and RFXDC2 (P = 10−15) (Fig 3B), among which HNF1B is known to be responsible for maturity-onset diabetes of the young (MODY) type 5 (Horikawa et al, 1997). The gene discussed is HNF1B; the disease is MODY.