Furthermore, each motif was similar to that of HNF1A, NEUROD1, FOXA2 (FOX:Ebox), and RFX6 (Fig 3B), which have been established as the causative or susceptible genes of human MODY3 (Yamagata et al, 1996), MODY6 (Malecki et al, 1999), T2D (Gaulton et al, 2015), and neonatal diabetes mellitus (Smith et al, 2010), respectively, suggesting the possible involvement of similar pathological mechanisms of human diabetes in KK-SH mice. This evidence concerns the gene RFX6 and type 2 diabetes mellitus.