HIF1A and Hematochezia: Surprisingly, HIF-1α KO mice exhibited a transiently enhanced disease activity that comprises weight loss, stool consistency, and hematochezia (Friedman et al, 2009) (Fig 1A) during the third DSS challenge and a worsened histological score at the endpoint (Fig 1B), despite a decrease in ILC1 frequencies (Fig 1C).