G6PD and steatosis: While HFD feeding did not increase ALT and AST in plasma of both genotypes (Table 1), IPA Tox analysis of the liver HFD dataset shows that fatty liver disease (steatosis) was significantly [activation z-score was −1.88 and -log10 (p-value) was 4.06] inhibited in response to G6PD mutation (Fig. 4E).