Interestingly, G6PD deficiency in mice reduces angiotensin II-induced hypertension and atherosclerosis (19, 20), and a loss-of-function Mediterranean G6PD (G6PDS188F) variant in rat reduces hypertension and large artery stiffness induced by feeding of HFD/obesogenic diet for 4 months (21). This evidence concerns the gene AGT and hypertensive disorder.