VEGFA and osteonecrosis: It wasobserved that the Mg implant significantly reduced the occurrenceof osteonecrosis-like lesions and increased bone microstructural parametersand expression of vascular endothelial growth factor A (VEGFA).58 These studies paved the way for further investigationof the effect of Mg-based implants on their proangiogenic effectsand potential for regeneration of vascularized bone tissue in largeranimal models.