The paraventricular nucleus, located in the anterior superior subregion, plays an essential role in energy and muscle homeostasis by producing hormones such as oxytocin.38 A previous postmortem study showed regional atrophy, TAR DNA-binding protein 43 (TDP-43) inclusions, and a loss of oxytocin-producing neurons in the paraventricular nucleus of patients with ALS.35 Perhaps the observed atrophy of the anterior superior subregion is caused by atrophy of the paraventricular nucleus because of degeneration of oxytocin-producing neurons. The gene discussed is OXT; the disease is amyotrophic lateral sclerosis.