The levels of caspase 8 (OR = 1.401, 95% CI = 1.108−1.770, P = .005), T-cell surface glycoprotein CD6 isoform (OR = 1.133, 95% CI = 1.024–1.254, P = .015), and leukemia inhibitory factor (OR = 1.477, 95% CI = 1.152−1.896, P = .002) were positively associated with scoliosis, suggesting that the genetic prediction of these 3 IFs was associated with an increased risk of scoliosis. The gene discussed is CASP8; the disease is scoliosis.