TSHR and cardiovascular disorder: However, owing to its rarity and often subtle symptoms, this condition is frequently misattributed to primary psychological conditions or gastrointestinal and cardiovascular disorders, leading to potential harm to developing children and adolescents.[39] Notably, pregnancy itself may cause palpitations and sweating, and increased estrogen secretion can elevate total serum thyroxine levels.[40] Since pregnant women cannot undergo radioactive testing, diagnosing GD during pregnancy is extremely challenging when the patient tests negative for TSH receptor antibodies.[41]