GD, an organ-specific autoimmune disorder, has been studied continuously, revealing novel findings related to its autoimmune response and inflammatory processes.[1,2] Janyga et al[62] identified a significant elevation in IL-23 and IL-31 levels in GD patients by measuring 15 cytokines associated with Th17 and Treg lymphocytes in the serum of different populations. This evidence concerns the gene IL31 and autoimmune disease.