Additionally, visual analysis of co-cited references revealed active citation relationships among the top 10 co-cited references, except for “Graves’ ophthalmopathy” by Bahn et al in 2010 and “Association of the T-cell regulatory gene cytotoxic T lymphocyte antigen-4 (CTLA-4) with susceptibility to autoimmune disease” by Ueda et al in 2003 (see Fig. 8). The gene discussed is CTLA4; the disease is autoimmune disease.