Evidence shows that BCAR4 increases expression of genes that drive cell stemness (KLF4, SOX2, and OCT3/4) by activating the Wnt/β-catenin pathway, thereby enhancing DDP resistance and stemness of GC cells.[22,23] Wang et al demonstrated that expression of the lncRNA ROR (a reprogramming regulator) positively correlates with poor prognosis and MDR in GC patients.[24] These reports highlight the feasibility of lncRNAs to diagnose and predict the prognosis of GC. This evidence concerns the gene SOX2 and gastric cancer.