TNF-α can transmit biological information to the nucleus of the cell through specific receptors present on the cell membrane to produce cytotoxicity, immunomodulation, antitumor, antiviral, inflammation-mediated, and other biological activities.[22] EGFR is a transmembrane protein whose expression plays an important role in initiating inflammatory factors.[23] EGFR can sometimes inhibit bacterial infections.[24] In summary, proteins such as AKT1, TNF and EGFR play important roles in the body’s antimicrobial, anti-infective, inflammatory and immune processes. The gene discussed is AKT1; the disease is bacterial infectious disease.