CDCA1 is a member of the centromere protein complex, which is evolutionarily conserved.[13] Also, CDCA1 is a prognostic marker and a potential immune target in multiple myeloma and prostate cancer.[34,35] Our analysis revealed that CDCA1 is expressed at high levels in LUAD and is associated with poor OS. This evidence concerns the gene NUF2 and Familial prostate cancer.