CBX2 and cancer: It has been reported to be overexpressed in multiple cancers, and it promoted cell proliferation by activating the PI3K/AKT/mTOR pathway.[17] CDCA6, also called CBX2, has been shown to shape chromatin accessibility to promote AML via the p38 MAPK signaling pathway.[18] It regulates proliferation and apoptosis by activating the phosphorylation of YAP.[19] CDCA7 expression is related to the migration and invasion of lymphoma,[20] and patients with CDCA7 overexpression have poorer prognosis in breast cancer.[21] CDCA8 also promotes the development of live cancer[22] and pancreatic cancer.[23]