In ICC, there are genetic abnormalities such as t(1;3)(p36.3;q21.3)/PRDM16::RPN1, t(10;11)(p12.3;q14.2)/PICALM::MLLT10, t(16;21)(q24.3;q22.1)/RUNX1::CBFA2T3, and ≥ 10% blast cells can diagnose AML subtypes, which are not recognized by the WHO.[14]. This evidence concerns the gene RPN1 and intrahepatic cholangiocarcinoma.