Recent studies have also shown that pyroptosis is closely related to idiopathic pulmonary fibrosis (IPF), and the increased expression of IL-1β and IL-18 in the serum and lung tissues of mice induced by bleomycin was observed in the IPF model [34]; moreover, pyroptosis is the direct cause of the increased expression of IL-1β and IL-18 in lung tissues [35]. This evidence concerns the gene IL18 and pulmonary fibrosis.