GRIA4 and early-onset autosomal dominant Alzheimer disease: NPTX2 binds to α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit Glutamate receptor 4 (GRIA4) in neuronal tissues [66] and has a presynaptic role in Pyramidal neurons with loss/loss of function associated with Alzheimer’s disease [67] and Schizophrenia [68].