PROCR and cerebral malaria: Using a DC8-EPCR–expressing parasite line that was selected in vitro on human brain endothelial cells [14] and typifies a subset of EPCR-binding variants that was linked to severe brain swelling in our pediatric cerebral malaria population in Southern Malawi [17], we observed a strong correlation between the level of flow cytometric recognition of IEs by plasma and adhesion-blocking capacity in 3D brain microvessels.