This supports the translational relevance of our animal work and confirms findings of earlier mRNA studies.27,64 Because AMY1 and CGRP receptor components were also detected in the migraine-related EWcp projection areas such as DRN and STN, we assume that the CGRP may activate the DRN and STN directly or indirectly through AMY1 and CGRP receptor-expressing EWcp/UCN1 neurons. This evidence concerns the gene UCN and migraine disorder.