The CGRP, released by central nerve endings, stimulates the CGRP receptor on second-order neurons in the caudal division of STN, contributing to central sensitization.8,46 The trigeminal activation during migraine attacks elevates CGRP level.39 Human studies have reported migraine-like attacks following intravenous CGRP infusion.40,60 Serotonin (5-HT) receptor agonists (sumatriptan, dihydroergotamine) restore baseline CGRP level38,85 concurrent with pain relief.50 Here, CALCA is linked to migraine disorder.