WNT6 and brachydactyly: Lupiáñez and colleagues described how heterozygous deletions on chromosome 2q35-36 that alter the higher-order chromatin organization of the WNT6/IHH/EPHA4/PAX3 locus can allow interactions between a cluster of limb enhancers, normally associated with EPHA4, and the PAX3 promoter region, leading to an ectopic limb expression of PAX3 and causing brachydactyly (Lupiáñez et al. 2015).