COPRS and Cognitive impairment: Consistently, deletion of ATAD5, NF1, RAB11FIP4, SUZ12, and COPRS genes n to may increase tumor risk in NF1 microdeletion patients (as reported by Kehrer-Sawatzki et al. 2017), while OMG deletion gene has been previously associated to cognitive impairment in this NF1 patients’ subgroup (Venturin 2004).