RASA1 and angioosteohypertrophic syndrome: RASA1 variants have been associated with vascular malformation syndromes characterized by hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM), arteriovenous fistulas (AVF), or Parkes Weber syndrome; however, the phenotypic spectrum of the constitutional variants of RASA1 is still being defined (Wooderchak-Donahue et al. 2018).