Consistently, deletion of ATAD5, NF1, RAB11FIP4, SUZ12, and COPRS genes n to may increase tumor risk in NF1 microdeletion patients (as reported by Kehrer-Sawatzki et al. 2017), while OMG deletion gene has been previously associated to cognitive impairment in this NF1 patients’ subgroup (Venturin 2004). This evidence concerns the gene OMG and Cognitive impairment.