In rodent models of cerebral ischemia (Xu et al. 2022), traumatic brain injury (Zhang et al. 2019), and chlorpyrifos neurotoxicity (Shou et al. 2019), enhanced Nrf2 expression provides support for the idea that Nrf2 signaling may be involved in the beneficial effects of EDV. This evidence concerns the gene NFE2L2 and brain ischemia.