Most importantly, the necessity of YAP/TAZ in the pro-fibrotic function of HSCs has been demonstrated in studies where pharmacological inhibition with verteporfin attenuated HSC activation and collagen production in vitro and reduced liver fibrosis in mouse models (Mannaerts et al. 2015; Martin et al. 2016; Du et al. 2018; Liu et al. 2019). This evidence concerns the gene YAP1 and Hepatic fibrosis.